Welcome - CompareCollegeTX.com:
'via Blog this'
This is very useful for comparing Texas colleges. The public ones, at least. I wonder if this exists for other states.
Tuesday, November 18, 2014
Thursday, November 13, 2014
Bitch: A History
I like scholarly work done on topics that we almost don't think about anymore.
Bitch: A History:
'via Blog this'
By Clare Bayley
at http://clarebayley.com/2011/06/bitch-a-history/
Bitch: A History:
'via Blog this'
By Clare Bayley
at http://clarebayley.com/2011/06/bitch-a-history/
Bitch: A History
This past semester at MIT I took a really wonderful class called “Feminist Political Thought” which had a very open ended essay assignment. I wrote a history of the word “Bitch,” and several of my classmates requested to read the whole paper so I thought I’d post it here. It’s actually quite interesting, if-I-do-say-so-myself.
Bitch is one of the most complicated insults in the English language. A bitch typically means a lewd, malicious, irritating woman (the comparison being to a dog in heat), but some women self-identify asbitches to indicate they are strong, assertive and independent. A son of a bitch is generally a despicable or otherwise hateful man, but can also mean a dear friend who has done something impressive or clever. If something is bitchin’ it is deemed to be particularly cool or in-style, but if a person is bitching they are complaining or whining. To be someone’s bitch is to be his or her servant or slave, to sit in the bitch seat is to sit in the under-sized seat in the middle of a car, to bitch slap is to strike with an open palm. Bitch might have originally meant a female dog, but now it can indicate anything from slapstick humor to scathing insult.
The rise of bitch through history can be traced to 4 distinct periods: The Definition, The Rise, the Reclamation, and the Popularization. The last 3 can be tied to specific events in American feminism.
[Author’s note: All of the data regarding the popularity of words through time come from Google’s Ngram viewer, which displays the prevalence of a word or words in Google’s Book Database. Neither Google nor I claim this database to be complete, but as it has over 15 million titles it is sufficiently representative of English publications for this analysis]
I: The Definition
Insulting a woman by calling her a female dog pre-dates the existence of the word bitch itself. The English language historian Geoffrey Hughes suggests the connection came about because of the Greek goddess of the hunt, Artemis (Diana in the Roman pantheon) who was often portrayed with a pack of hunting dogs and sometimes transformed into an animal herself. In Ancient Greece and Rome the comparison was a sexist slur equating women to dogs in heat, sexually depraved beasts who grovel and beg for men1.
The modern word bitch comes from the Old English bicce, which probably developed from the Norse bikkje, all meaning ‘female dog’. Its use as an insult was propagated into Old English by the Christian rulers of the Dark Age to suppress the idea of femininity as sacred. The insult “son of a bitch” (biche sone in Old English) originated to ridicule spiritual pagans, who worshipped the bitch goddess Diana1. The phrase evolved to mean a generally despicable or otherwise hateful man. Shakespeare, that master of verbal barbs, uses the insult twice in his plays. Once in Troilus and Cressida (1602), in the opening of Act II as Ajax comes upon Thersites2.
Thou bitch-wolf’s son, canst thou not hear?[beating him]Feel, then.
And again in King Lear (1606), when the Earl of Kent is greeting Oswald2:
…[thou] art nothing but the composition of a knave, beggar, coward, pander, and the son and heir of a mongrel bitch.
Interestingly, nowhere in his collected works does Shakespeare ever use the word to insult a woman. At first, one might think this reveals a chivalrous objection to insulting women – but a similar search forwhore reveals five pages of results. As a playwright known for his imaginative (and numerous) insults, his omission of bitch as a female insult indicates something about the common usage of the word in his time. In fact, much of the documented usage of the word from the 16th and 17th centuries is in reference to a man, not a woman. In Henry Brinklow’s 1524 Complaynt of Roderyck Mor, he calls out the hypocrisy of the clergy for valuing un-wed chastity by describing the bishops “as chast as a sawt bytch.”3 In modern English: “as pure as a randy bitch.” An early 16th century manuscript known only as “The Porkington Manuscript” includes a re-telling of a humorous story about a Friar and a cheeky Boy. The Friar, complaining of the Boy’s antics, says “Be God, he ys a schrewd byche, In fayth, y trow, he be a wyche.” In modern English: “By god, he is a shrewd bitch. In faith, I know, he is a witch.”4
It seems the Dark Age Christian attempt to re-purpose the insult worked. While the word by itself may have described a female entity, its abusive power at the end of the Middle Ages lied in its application to a man – not only putting him down by calling him a woman, but further dehumanizing by equating him with a dirty female animal.
The 18th century saw a return to the original insulting meaning of bitch. Indeed, use of the insult grew so dominant that it finally forced the literal meaning of the word, that of female dog, out of common circulation. While science publications and dog enthusiast communities retained the word bitch, various euphemisms such as doggess, lady dog, she dog, and puppy’s mother were more commonly used1. The usage of bitch held steady for the next 200 years. At the cusp of the 20th century, Slang and its Analogues gave a succinct definition and partial history of the term5.
Bitch:
- An opprobrious term for a woman, generally containing an implication of lewdness and ‘fastness.’ Not now in literary use, though formerly so. [From its primary sense of a female dog] It is the most offensive appellation that can be given to an English woman, even more provoking than that of whore.
- (old) Applied, opprobriously, as in sense 1, to a man. It has long since passed out of decent usage.
II: The Rise
The first serious rise in the usage of bitch begins at 1920 – exactly the same year as another feminist milestone in the United States: suffrage. The 19th amendment to the US constitution was ratified on August 18th, 1920. After decades of struggle, women finally received the right to vote. But as women became more public, so too did their critics. Now that women were appearing more and more on the American stage, the insult bitch began to slip slowly into popular discourse.
Of the books published in 1915 that contain the word “bitch,” all are journals of dogs or veterinary medicine, law books explaining cases involving dogs, and the occasional court case in which the transcript includes some man calling another a “son of a bitch.”
Within the books published in 1925, merely 10 years later but on the other side of the 19th amendment, there is fiction, magazine articles, and even some quotes from news sources that use bitch to insult a woman. Through the years this trend continues – in fact, by 1930 references to the word as an insult to a woman outnumber the references to a female dog.
So what changed?
The answer lies in the connotation of the insult itself. Of the publications from this period, the uses ofbitch can be grouped into three categories of meaning:
- Malicious or consciously attempting to harm
- Difficult, annoying, or interfering
- Sexually brazen or overly vulgar
These three traits combined form a perfect picture of the angry 1st wave feminist that many suffragist opponents feared, a kind of anti-lady. The dystopia predicted by those opponents, both men and women, is summed up well in remarks made by a Representative from Alabama in 19186:
There will be no more domestic tranquility in this nation. No more “Home Sweet Home,” no more lullabies to the baby. Suffrage will destroy the best thing in our lives and leave in our hearts an aching void that the world can never fill.
Angry, dangerous, and independent, these suffragists had stomped in and broken up the status quo, interfering in the lives of ordinary folk and harming the “domestic tranquility” that had been the pinnacle of American happiness. This was a new type of woman, one America hadn’t been forced to seriously consider before. There had to be a name for these women. They found one: these new feminists were a bunch of uppity, interfering bitches.
III: The Reclamation
The popularity of bitch dipped slightly around the late 30s and early 40s, possibly due to an increase of chivalry and respect towards the women who played an important part in the war effort (or just because everyone had better things to write about). After the war, use of the word popped back up and continued steadily until around 1965 when it experienced a sudden rise in use.
Again we see a correlation with a significant change in the feminist movement. 1963 saw both the publication of The Feminine Mystique by Betty Friedan, and the release of the final report of the Presidential Commission on the Status of Women7 8. Both bemoaned the poor status of women in an apparently free and equal society, both brought forth the startling notion that women who lived the life of a perfect housewife might have many good reasons to not be happy. These ideas sparked the 2nd wave of feminism which, after the success of the 1st wave in removing many legal barriers to equality, moved on to addressing women’s issues in the home, the workplace, the family, and in their own reproductive rights.
The 1960’s found women gaining a sense of pride in many of the things their opponents criticized them for: assertiveness, strength, independence, and a willingness to fight for their own definition of happiness. In 1968, Jo Freeman (Joreen) published The BITCH Manifesto, a document that defines the bitches of 2ndwave feminism9.
Our society has defined humanity as male, and female as something other than male. In this way, females could be human only by living vicariously thru a male. To be able to live, a woman has to agree to serve, honor, and obey a man and what she gets in exchange is at best a shadow life. Bitches refuse to serve, honor or obey anyone. They demand to be fully functioning human beings, not just shadows. They want to be both female and human.
Suddenly, the ideal qualities of a feminist and the definition of a bitch matched up. Feminists began to self-identify as bitches, and use it in their writings. The insult became a rallying cry, a signal to women that these things that have hurt us can be changed for the better. All these things women used to be insulted for now became a goal.
We must be strong, we must be militant, we must be dangerous. We must realize that Bitch is Beautiful and that we have nothing to lose. Nothing whatsoever. (close of the BITCH Manifesto)9
IV: The Popularization
By the time Feminism began its 3rd wave, reclaiming bitch was an official part of many feminist’s agenda. 1996 saw the first publication of Bitch Magazine, a periodical giving a “feminist response to pop culture.”10 One of the magazine’s founders, Andi Zeisler, explained in a 2006 interview that they chose the name explicitly because they wished to reclaim the word11.
When we chose the name, we were thinking, well, it would be great to reclaim the word “bitch” for strong, outspoken women, much the same way that “queer” has been reclaimed by the gay community. That was very much on our minds, the positive power of language reclamation.
Due to the efforts of Zeisler and many others, bitch began appearing everywhere – on bookshelves, on clothing, on food labels, and in the words of popular media. Being a bitch wasn’t just for feminists anymore. Shirts with “You Messed with the Wrong Bitch!” on them started selling in children’s sizes. Buttons saying “The Birthday Bitch” appeared in novelty shops. In 1999 best selling author Elizabeth Wurtzel published Bitch: In Praise of Difficult Women12. In it, she lays out a view of bitch that was a bit different from Joreen’s BITCH Manifesto.
I intend to scream, shout, race the engine, call when I feel like it, throw tantrums in Bloomingdale’s if I feel like it and confess intimate details about my life to complete strangers. I intend to do what I want to do and be whom I want to be and answer only to myself: that is, quite simply, the bitch philosophy.
The idea of self-reliance and a freedom to chase their own desires remained, but now bitches weren’t outcasts. Bitches shopped at Bloomingdales, bitches socialized with other women, telling intimate details to strangers. Bitches had become public.
It wasn’t just feminists that started popularizing the word. The 1990’s saw the rise of “Gangsta rap,” a style of hip hop that often contained profanity and descriptions of violence towards women. A 1991 album by “Bust Down” was titled Nasty Bitch, and featured an anthropomorphized dog stomping a woman’s head into the ground on the cover13. Along with the continuing reclamation of the word came a backlash that increased the use of bitch as a violent insult.
V: Modern Day
Nowadays people can read a diet book titled Skinny Bitch, drink many varietals of Sassy Bitch Wine, make new friends at a “Stitch ‘n Bitch” knitting club, listen to Meredith Brooks sing “I’m a bitch, I’m a lover, I’m a child, I’m a mother” or dance to Ludacris’ stirring lyrics “Move bitch, get out the way, get out the way bitch, get out the way.”
Bitch has come a far way from the “most offensive appellation” to women it was at the end of the 20thcentury. The 1st wave feminists of the 1920’s gave it an identity, the 2nd wave feminists grabbed it from the voices of their critics and reclaimed it as theirs, and the 3rd wave brought it forth, polished it up, and presented it to the world. From biche sone to bitch, please, the word has had a long and busy history, making it now one of the most common, and most complicated, swear words in America.
Bibliography:
1 Hughes, Geoffrey. An Encyclopedia of Swearing: The Social History of Oaths, Profanity, Foul Language and Ethnic Slurs in the English-Speaking World. M.E Sharpe Inc., 2006. The definition of “Bitch” appears on pages 23 and 24.
2 Shakespeare, William. Complete Works. Available online at www.opensourceshakespeare.org
3 Brinkelow, Henry. Henry Brinklow’s Complaynt of Roderick Mors. London, N. Trubner & Co., 1876.
4 Haliwell, Esq., J. O. English Miscellanies in Prose and Verse, selected form an inedited manuscript of the fifteenth century. Printed in London for the Warton Club, 1804.
5 Farmer, John S. Slang and its Analogues, past and present. Vol. 1 – A to Byz. 1790.
6 http://www.digitalhistory.uh.edu/database/article_display.cfm?HHID=258
7 Friedan, Betty. The Feminine Mystique. W. W. Norton & Co., 1963.
8 Presidential Commission on the Status of Women. The Presidential Report on American Women. October 1963.
9 Freeman, Jo. The BITCH Manifesto. 1968. Available online www.jofreeman.com/joreen/bitch.htm
10 Bitch Magazine’s “about us” page. http://bitchmagazine.org/about-us
11 Solomon, Deborah. Pop Goes the Feminist, and interview with Andi Zeisler. The New York Times, August 6th, 2006.
12 Wurtzel, Elizabeth. Bitch: In Praise of Difficult Women. Anchor, 1999.
13 Bustdown. Nasty Bitch [Explicit]. Lil’ Joe Records, 1991.
Friday, September 5, 2014
Lost: Why Ben Linus is the Best Villain Ever
Lost: Why Ben Linus is the Best Villain Ever
xRECKONERx wrote this in the Best Villian of 2014 thread on mafiascum.net. Since I think it captures the real essence of my feelings of Ben, want to post it here so I'll always have it.
But... Lost is a personal show for many reasons. You can knock it for all you want... incongruent philosophies, not making sense, an unrewarding payoff, and I'll probably at least sympathize with you. But Ben Linus, as portrayed by Michael Emerson, is one of the most brilliantly written and best performed villains in television history. He's the type of villain that you hate, and yet you find yourself feeling sorry for at your core, and it makes you question yourself. He's the type of villain that you love to hate to see commit these awful crimes... yet, when he does, you see a bit of humanity underneath. He's the type of villain that is only ever solely out for personal gain, but you put yourself in his shoes so well, that you find yourself rooting for him. He's the type of villain that makes you question a little bit of yourself, because he's not all that awful, right? He shows his humanity. But at the end of the day, he did these awful things that make it hard to really admit you root for him.
Ben Linus came around pre-Game of Thrones and pre-Breaking Bad, where rooting for evil characters wasn't commonplace in television. He was a villain, through and through, always working contrary to the protagonists' desires and plots. But... the writing, the way Emerson portrayed him, his place in the timeline of the show... it made it so difficult to hate him. That's why he's brilliant. I would argue that Emerson put on the best villainous performance in television in the past 20 years, with Bryan Cranston as Walter White, James Gandolfini as Tony Soprano, and maybe Giancarlo Esponito as Gus Fring in contention for the title. He just owned the role, and despite the complaints against Lost's inconsistent writing, the one part that is arguably perfect is the role of Ben Linus.
Thanks Reck!!
Tuesday, August 26, 2014
38 maps that explain the global economy - Vox
38 maps that explain the global economy - Vox:
'via Blog this'
I love maps. And these are cooler than most.
http://www.vox.com/2014/8/26/6063749/38-maps-that-explain-the-global-economy
'via Blog this'
I love maps. And these are cooler than most.
http://www.vox.com/2014/8/26/6063749/38-maps-that-explain-the-global-economy
Sunday, August 17, 2014
Angelo State University Men's High Rise
Thought I already posted about it, but I lived here on the 4th floor in 1989-1990 school year. It was 2 roommates sharing a bathroom with 2 more roommates in a "suite".
Great times, as the 4th floor was a bunch of sophomores plus the few new freshmen that got slots that were open, so everyone was a year ahead and grudgingly yet willingingly let us join the family.
Here's a write-up, since they blew the place up (or imploded it, actually, and that link is below).
From the website: http://www.gosanangelo.com/news/rick-smith-the-short-history-of-a-tall-building
Great times, as the 4th floor was a bunch of sophomores plus the few new freshmen that got slots that were open, so everyone was a year ahead and grudgingly yet willingingly let us join the family.
Here's a write-up, since they blew the place up (or imploded it, actually, and that link is below).
From the website: http://www.gosanangelo.com/news/rick-smith-the-short-history-of-a-tall-building
RICK SMITH: The short history of a tall building
Rick Smith
5:56 PM, Oct 25, 2009
5:58 PM, Oct 26, 2009
SAN ANGELO, Texas - One of my Facebook friends said it best: “There goes a third of the skyline!”
Love them or hate ’em, Angelo State University’s twin high-rise dormitories have been San Angelo landmarks for four decades.
When the original building, first called the Women’s High-Rise and now known as University Hall, comes tumbling down this morning, it will mark the end of an era.
I figure our first high-rise dorm deserves an obituary. Here’s a short history of the tall building:
* Aug. 7, 1966 — A story in the Standard-Times announced Angelo State College “officials are firming up plans for a new classroom building, twin high-rise dormitories and food service and a new science building as work progresses on the new $1.5 million library.”
* Sept. 29, 1966 — University officials predicted an enrollment of 7,500 students by 1978, with 5,000 of the students living in dormitories. The campus master plan, developed by architects Max Lovett and Gene Sellars, called for eight high-rise dormitories in all.
* June 1967 — The last of $3.5 million in bonds to pay for the new high-rise dormitory were sold in New York.
* July 1967 — Workers began digging the building’s basement.
* August 1967 — Locus Construction Co. of Abilene, the building’s contractor, completed the last of the foundation piers for the dorm.
* Dec. 15, 1967 — A photograph in the Standard-Times showed a skeletal frame of a 10-story freight elevator at the work site. On top of the framework perched a frost-covered Christmas tree.
* Feb. 5, 1968 — Alan Hatler, a 29-year-old construction worker from Garland, fell seven stories from the dorm and was pronounced dead on arrival at Shannon Hospital.
A spokesman for Locus Construction Co. said the worker “lost his footing” while doing concrete form work on the building.
Peace Justice O.L. “Pop” Miller ruled the death accidental.
* February 1968 — ASC held a pre-construction conference with architects, builders and others to discuss the construction of a second high-rise dormitory and a new food service center. Projected completion date for the food center was set for September 1968. Completion date for the men’s dorm was a year after that.
* March 1968 — Working “full speed ahead,” McDonald Brothers of Fort Worth began attaching precast marble wall panels on the south and north walls of the dorm. A crane hoisted the panels into place on the concrete skeleton of the building.
* April 1968 — Despite spring rains and difficult winter weather, contractors said the dorm was “about two-thirds complete” and “right at schedule” to be completed by Sept. 1.
* April 1968 — The university accepted bids for 2,775 square yards of carpet for the women’s dormitory. Carpet for the dorm’s formal lounge “will be top quality carpet,” the bid specified, while carpet for the living areas must be “highly stain resistant and easily cleaned.”
* Sept. 9, 1969 — A black and white photo in the Standard-Times showed the lights glowing on every floor of the completed building.
The lights, the caption said, “give a ‘big city’ look to the San Angelo skyline at night.”
* Sept. 10, 1968 — ASC President Lloyd D. Vincent squelched rumors that the new dorm would not open by the time fall registration began on Sept. 23.
* Sept. 18, 1968 — Board of Regents officials and other officials inspected the building and gave it their approval for occupancy.
* Sept. 19, 1968 — Workers, laboring 10 hours a day, seven days a week, continued installing draperies and carpet.
* Sept. 20-21, 1968 — Last-minute clean up and touch-up work continued. Details included the planting of shrubbery and St. Augustine grass around the outside of the dorm.
* Sept. 22, 1968 — At 2 p.m. on a Sunday afternoon, the dorm’s doors opened to the first residents, who began moving into the new building.
* Sept. 29, 1968 — Construction began on the Men’s High-Rise Dormitory.
* September 1969 — Angelo State University’s long-range planning committee indicated the high-rise style of construction for dormitories could be discontinued.
“The possibility of moving away from the high-rise concept came as a surprise because six to eight similar dorms are planned,” a Standard-Times reporter wrote.
* Fall 2004 — The Women’s High-Rise, renamed University Hall, was vacated after studies showed renovating or converting the building to other uses would be cost-prohibitive.
* Oct. 25, 2009 — If all goes as planned, ASU’s first skyline-altering “big city” building will drop from the sky shortly after sunrise.
Rick Smith is a local news and community affairs columnist. Contact him at rsmith@gosanangelo.com or 659-8248.
Thursday, May 22, 2014
Tuesday, May 20, 2014
Tuesday, May 6, 2014
Game of Thrones Summary - S04E05
Game of Thrones Season 4, Episode 5
"First of His Name"
A Summary of What's Going On
Tommen Lannister is crowned King of Westeros.
So, Daenerys Targaryen learns that being boss isn’t all
fun and games and having dragons burn shit down. So she skips the first boat
back to Westeros to take care of business is Essos. Smart move. It’s called
consolidating your reign before you bite off more than you can chew.
Map of Slavers Bay
Cersei finally figures out that Margaery is what’s best for
her son. Again. Either that or she is setting up Margaery again. But, when she’s
talking to dad later on, she seems to be all on board the Tyrelle marriage
train. (We also learn that the Lannister’s massive wealth is just a we bit less
massive than it was before). However, further conversation seems to indicate
she’s merely trying to get in Tywin’s good graces in order to influence the
verdict on Tyrion. This becomes especially apparent when she hits up
Prince Oberyn for the same thing- to fry her brother.
Cersei
Sansa is “rescued” by Baelish, and taken to her Aunt Lysa.
The family reunuion is somewhat awkward. Cousin Robin takes Sansa to her room,
and we find out Petyr has been a lot more naughty than we give him credit for.
His punishment is to marry Lysa, who is only his second choice, but at least
she’s alive (if crazy). This crazy comes out when she has a snack with Sansa
and accuses her of sleeping with Petyr. Sansa cries her way out of it, but then
is hit with the news of her impending nupitals to Robin, her cousin (who is
also hosting bats in his belfry, it seems to me).
Sansa
Jon Snow leads his band of merry Crows to Craster’s Keep to
take care of some deserters. Turns out one of them is some sort of Brandon fan,
and he tries to kidnap him. Brandon takes him down, and on the advice of his
companions, hides from Jon in order to continue North. Jon at least gets his
wolf back.
Jon
Saturday, April 19, 2014
Video Games Do Cause Aggression... If They Suck | Techdirt
Video Games Do Cause Aggression... If They Suck Out Loud | Techdirt:
'via Blog this'
from techdirt.com (http://www.techdirt.com/articles/20140408/11333326840/video-games-do-cause-aggression-if-they-suck-out-loud.shtml)
Video Games Do Cause Aggression... If They Suck Out Loud (via Techdirt)
I think I've come to the realization that the debate over whether violent video games cause real-life violence is probably never going to end. Centuries from now, some new race of alien beings will be picking over humanity's remains like some kind of…
'via Blog this'
from techdirt.com (http://www.techdirt.com/articles/20140408/11333326840/video-games-do-cause-aggression-if-they-suck-out-loud.shtml)
Video Games Do Cause Aggression... If They Suck Out Loud (via Techdirt)
Friday, April 11, 2014
Loss
In closing, I want to describe the final scene from "Peter and the Star Catcher," which is the prequel to "Peter Pan." Molly (who later had a daughter named Wendy) and her dad were getting ready to go home and couldn't take Peter with them. There was great sadness on the part of both Peter and Molly. Molly's dad assured Peter that soon he would forget, and it wouldn't hurt anymore. "But it's supposed to hurt." said Molly. "That's how you know it really meant something."
Thursday, March 27, 2014
Brain Changes Suggest Autism Starts In The Womb
A study that shows Autism most likely occurs during brain development (of the brain cortex).
Brain Changes Suggest Autism Starts In The Womb : Shots - Health News : NPR:
'via Blog this'
from the website:
http://www.npr.org/blogs/health/2014/03/26/294446735/brain-changes-suggest-autism-starts-in-the-womb
iStockphoto
Brain Changes Suggest Autism Starts In The Womb : Shots - Health News : NPR:
'via Blog this'
from the website:
http://www.npr.org/blogs/health/2014/03/26/294446735/brain-changes-suggest-autism-starts-in-the-womb
Brain Changes Suggest Autism Starts In The Womb
by JON HAMILTON
The symptoms of autism may not be obvious until a child is a toddler, but the disorder itself appears to begin well before birth.
Brain tissue taken from children who died and also happened to have autism revealed patches of disorganization in the cortex, a thin sheet of cells that's critical for learning and memory,researchers report in the New England Journal of Medicine. Tissue samples from children without autism didn't have those characteristic patches.
Organization of the cortex begins in the second trimester of pregnancy. "So something must have gone wrong at or before that time," says Eric Courchesne, an author of the paper and director of the Autism Center of Excellence at the University of California, San Diego.
The finding should bolster efforts to understand how genes control brain development and lead to autism. It also suggests that treatment should start early in childhood, when the brain is capable of rewiring to work around damaged areas.
The study grew out of research by Courchesne on development of the cortex in children with autism. In typical kids, the cortex is "like a layer cake," he says. "There are six layers, one on top of the other, and in each layer there are different types of brain cells."
Courchesne suspected that these layers might be altered in the brains of children with autism. So he and a team of researchers studied samples of cortex from 11 children with autism and an equal number of typical kids. The cortex came from areas known to be associated with the symptoms of autism.
In the brain tissue from typical children, the cortex had six distinct layers, each made up of a specific type of cell. But in the children with autism, "there are patches in which specific cells in specific layers seem to be missing," Courchesne says. So instead of distinct layers, there are disorganized collections of brain cells.
These patches of disorganized cortex would have different effects on the brain depending on where they occur and how many there are, Courchesne says. That could help explain why the symptoms of autism vary so much.
And finding that the damage isn't everywhere suggests how a child's brain might compensate by rewiring to avoid the trouble spots, Courchesne says. "That's one of our guesses about how it is that autistic children, with treatment, very commonly get better," he says.
The new study appears to confirm research from the University of California, Los Angeles showing that people with autism tend to have genetic changes that could disturb the formation of layers in the cortex.
And it adds to the already considerable evidence that autism starts in the womb, says Dr. Stanley Nelson, a geneticist at UCLA. "The overwhelming set of data is that the problems are existing during brain development, probably as an embryo or fetus," he says.
But some of the new study's findings are surprising and even a bit perplexing, Nelson says. For example, it's odd that only certain bits of brain tissue contain these disorganized cells. "Why is the whole cortex not disorganized?" he says.
It's also odd that 10 of the 11 children with autism had the same sort of disorganized patches of cortex, Nelson says. That's not what you would expect with a disorder known to involve many different genes, presumably affecting many different aspects of brain development.
So he'd like to know what researchers would find if they looked at hundreds of brains instead of just a few. "What fraction of all the kids with autism are going to have these small patches?" he says. "I think the jury's out on that."
Nelson is right that there's no clear answer yet, says Ed Lein, one of the paper's authors and an investigator at the Allen Institute for Brain Science in Seattle. But it's possible that many different combinations of genes involved in autism could lead to the same patches of disorganization in the layers of cortex.
Finding out whether that's the case will be difficult because there is a shortage of brains from children available to researchers. Parents of children who die — with and without autism — rarely agree to donate their child's brain to science.
Scientific and advocacy groups are trying to change that with a program that informs families about tissue donation and a website that encourages people with autism and their families to get involved in research projects.
Transcript:
Copyright ©2014 NPR. For personal, noncommercial use only. See Terms of Use. For other uses, prior permission required.
AUDIE CORNISH, HOST:
Children who have autism usually don't get diagnosed before the age of four. But a study published in the current issue of The New England Journal of Medicine suggests the disorder starts well before birth. The findings should bolster efforts to understand how genes control brain development and contribute to autism. NPR's Jon Hamilton reports.
JON HAMILTON, BYLINE: About halfway through pregnancy, the brain of a fetus starts to get organized. Eric Courchesne, an autism researcher at UC San Diego, says this process is especially important in the cortex, a thin sheet of cells that's critical for learning and memory.
ERIC COURCHESNE: This sheet is like a layer cake. There are six layers, one on top of the other. In each layer, there are different types of brain cells.
HAMILTON: Courchesne suspected that these layers might be altered in the brains of children with autism. So he and a team of researchers studied samples of cortex from 22 children who had died. The cortex came from areas known to be associated with the symptoms of autism. Courchesne says some of the samples came from typical children, others from children with the disorder.
COURCHESNE: In autistic cortex, there are patches about five millimeters to 10 millimeters in diameter in which specific cells in specific layers seem to be missing.
HAMILTON: In these patches, Courchesne says, instead of distinct layers, there are disorganized collections of brain cells without clear boundaries. He says this almost certainly means that something went wrong very early in brain development.
COURCHESNE: Somewhere between around 19 weeks gestation and about 30 weeks of gestation, the cortex begins to develop clear distinct layers. So something must have gone wrong at or before that time.
HAMILTON: Courchesne says these patches of disorganized cortex would have different effects on the brain, depending on where they occur and how many there are. That could help explain why the symptoms of autism vary so much. Courchesne says it also suggests how a child's brain can compensate for the damage by rewiring.
COURCHESNE: There may be some cortical areas that are less affected. And therefore, rewiring around these patches may, in some individuals, be successful leading to improved functions. That's one of our guesses about how it is that autistic children with treatment very commonly get better.
And it suggests that treatment should start early in childhood in order to encourage as much rewiring as possible. The new study appears to confirm research from UCLA showing that people with autism tend to have genetic changes that could disturb the formation of layers in the cortex.
HAMILTON: Stan Nelson, a psychiatrist at UCLA, says the study also adds to the considerable evidence that autism starts in the womb.
DR. STAN NELSON: The overwhelming set of data is that the problems are existing during brain development, probably as an embryo or fetus.
HAMILTON: But Nelson says some of the new study's findings are surprising and even a bit perplexing. For example, he says, it's odd that only certain bits of brain tissue contain these disorganized cells.
NELSON: Why are we just seeing them in small patches? Why is the whole cortex not disorganized?
HAMILTON: Nelson says it's also odd that 10 of the 11 children with autism had the same sort of disorganized patches. He says that's not what you would expect with a disorder that's known to involve many different genes, presumably affecting many different aspects of brain development. So he'd like to know what researchers would find if they looked at hundreds of brains instead of just a few.
NELSON: What fraction of all the kids with autism are going to have these small patches? I think the jury's out on that.
HAMILTON: The study's authors agree. But they say the patches may turn out to be a common feature of autism. Finding out for sure will be difficult. That's because this sort of research can't happen unless parents of children who die agree to donate their child's brain to science.
Jon Hamilton, NPR News.
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